Buy Vilon (Lys-Glu, KE) Dipeptide Bioregulator

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Order a sealed 10-vial research pack , or add a single-vial laboratory sample alongside your pack to evaluate a compound at smaller scale first. Same source — scaled to whatever your research needs.

Scientific Research Context

What the published literature on Vilon examines. These are findings about the compound in the studies cited, not claims about the supplied material.

Lifespan and tumours in mice

Two reports from 2000 followed mice given Vilon. In female CBA mice dosed under the skin from the sixth month, the authors reported higher activity and endurance, lower body temperature, longer survival and fewer spontaneous neoplasms, and no adverse effect on development. [animal, mouse]

Induced bladder tumours in rats

In rats with chemically induced bladder tumours, tumour incidence was reported as 56% with Vilon against 75.5% in controls, and early changes in the bladder lining were reported as lower. Epitalon, tested in the same study, showed no such inhibition. [animal, rat]

Interleukin-2 expression in lymphocytes

In cultured mouse spleen lymphocytes, Lys-Glu stimulated expression of the interleukin-2 gene, with the size of the effect depending on concentration and exposure time. [in vitro, mouse cells]

Mouse heart microarray

On a 15,247-clone cDNA array, 300 clones changed more than twofold across the treatments compared: 36 with Vilon, 98 with Epitalon and 144 with the two together. [animal, mouse]

Human mesenchymal stem cells

In cultured human mesenchymal stem cells, KE was reported to raise SIRT1 expression and protein synthesis in younger cells and to lower PARP1 and PARP2 expression and protein synthesis in ageing cultures. Modelling suggested contact with promoter DNA sequences. [in vitro, human cells; in silico]

Peptide versus free amino acids

In organotypic rat spleen cultures, Lys-Glu stimulated proliferation while a mixture of free lysine and glutamic acid inhibited it. Docking suggested stronger DNA minor-groove contact for the dipeptide than for either amino acid. [ex vivo, in silico]

Overview

In short: Vilon (Lys-Glu, "KE") is a two-residue synthetic peptide from the Khavinson bioregulator family, examined in rodent studies, lymphocyte culture, microarray work and human stem-cell culture.

Key research facts

Synthetic Lys-Glu (KE) dipeptide, the two-residue member of the Khavinson short-peptide lineage

Examined in life-long mouse experiments that tracked tumour occurrence and survival

Studied for interleukin-2 gene expression in mouse spleen lymphocytes in culture

Profiled against Epitalon on a 15,247-clone mouse heart microarray

Tested in 2023 for SIRT1, PARP1 and PARP2 expression in ageing human mesenchymal stem cells

These points summarise lab themes, not human outcomes.

Only two amino acids make up KE: lysine, whose side chain carries a positive charge, and glutamic acid, whose side chain carries a negative one. Longer family members are built on the same pair. Testagen is Lys-Glu with Asp-Gly added, and Vesugen is Lys-Glu-Asp. Because the molecule is so small, one report compared Lys-Glu with a mixture of the free amino acids to ask whether the peptide bond itself matters.

The older papers are from 2000 to 2002 and are mostly mouse and rat work. Female CBA mice given the peptide from six months of age were followed for activity, body temperature, spontaneous tumours and survival. A rat study counted induced bladder tumours. Another measured digestive enzymes in young and older rats. A newer paper, published in 2023, moves to cultured human mesenchymal stem cells and measures gene and protein levels.

Almost all of it comes from one research network, and no controlled human trial is cited on this page. Vilon is supplied here as a lyophilised research powder for in-vitro and preclinical use. No analytical report for the supplied material has been published yet, so no purity figure is quoted.

Research class: Synthetic short-peptide bioregulator (Khavinson family)

Sequence: Lys-Glu (KE)

Research focus: Lifespan and tumour endpoints in rodents; interleukin-2 and sirtuin or PARP gene expression in cells

Evidence base: Mouse, rat, lymphocyte-culture and stem-cell studies, largely one research network; no human trial cited

Proposed Mechanism

Vilon is studied within the Khavinson model, in which very short peptides reach the cell nucleus and interact with DNA to change gene expression. For this dipeptide the support is expression measurements and docking, not a demonstrated pharmacology.

Pathway Effect Why it matters Interleukin-2 transcription Lys-Glu stimulated interleukin-2 gene expression in cultured mouse lymphocytes The clearest single-gene readout; dependent on dose and time, shown in cells only Genome-wide expression screen 36 of 15,247 clones changed more than twofold in mouse heart with Vilon alone Shows a measurable footprint in one tissue; says nothing about thymus or any other organ Sirtuin and PARP genes Higher SIRT1 and lower PARP1 and PARP2 reported in ageing human stem-cell cultures Human cells, but a short in-vitro report from the originating group Peptide-bond dependence Dipeptide and free-amino-acid mixture gave opposite results in spleen culture Indicates the bonded form behaves differently from its parts in that assay

Deeper dive for scientific readers

The proposed route runs from uptake into the cell, through nuclear entry, to binding at specific promoter sequences. For KE the cited evidence for each step differs. Expression changes are measured in mouse lymphocytes, mouse heart and human stem cells. DNA contact is shown by molecular docking rather than by a binding assay on chromatin. The whole-animal results, from tumour counts to survival, were obtained in rodents by the originating laboratory, and the abstracts give no group sizes for several of them. None of this has been independently replicated in the papers cited.

Common Questions People Are Asking

What is Vilon?

Vilon is the name used for the synthetic dipeptide Lys-Glu (KE) in publications from the Khavinson group. It is a research peptide with a preclinical record, supplied here as a lyophilised powder for laboratory use only.

Why is a two-residue peptide in the same family as the tetrapeptides?

The Khavinson programme grouped ultrashort peptides by their proposed ability to act on gene expression. Lys-Glu is the shortest of them and is the first two residues of both Lys-Glu-Asp (Vesugen) and Lys-Glu-Asp-Gly (Testagen).

What did the cited studies measure?

Mouse tumour occurrence and survival, rat bladder-tumour incidence and digestive-enzyme activity, interleukin-2 expression in lymphocyte culture, a mouse heart microarray, and SIRT1, PARP1 and PARP2 expression in human stem-cell culture. Each is described on this page as reported by its authors, and all of it is preclinical.

Is there a Certificate of Analysis for Vilon?

Not yet. No analytical report has been published for this material, so no purity figure is quoted.

Is there human data on Vilon?

The only human material in the cited literature is cultured mesenchymal stem cells; no study in people is cited. Vilon is sold strictly for in-vitro and preclinical research, not for human or veterinary use.

Where can I buy Vilon?

Right here - Vilon is supplied directly by New-U Research Compounds on this page, as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging.

How much does Vilon cost?

Vilon pricing is shown live on this page, per pack size - 10-vial research packs as standard, with single-vial sample options on selected compounds. Shipping is free on orders over $350.

How do I buy Vilon?

Add the Vilon pack size you need to your cart and check out: enter your shipping details, then choose your payment method - cryptocurrency or card - on the next step.

What payment methods can I use to buy Vilon?

At checkout you can pay by card or crypto. New-U supports BTC and selected stablecoin and network-asset payments across Ethereum, Solana, TRON, Polygon, Base, BNB Chain and Linea. You choose your method after confirming your order.

How fast is shipping, and do you ship worldwide?

Yes - we ship worldwide in discreet, unmarked, tracked packaging; lyophilised peptides are stable through the tracked transit window. Delivery typically takes 6–14 business days, and shipping is free on orders over $350.

Is it legal to buy Vilon?

In the United States, Vilon is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction - buyers are responsible for compliance in their own region.

Research use only - all claims made on this site are for testing and research use only.

Pharmacokinetics

Stability Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Notes Laboratory research material. No human dosing exists for this compound and none is published or recommended here.

Evidence Tier

Overall: Tier 3: Limited / anecdotal

Vilon has a preclinical record that spans mice, rats, rodent lymphocytes and a recent human stem-cell culture, mostly from one St. Petersburg network. Several abstracts give no group sizes. No controlled human trial and no independent replication appear in the cited literature. It is supplied as unapproved laboratory material.

Tier 2 · Animal

Spontaneous neoplasms, activity, body temperature and survival in female CBA mice dosed from six months of age

Induced bladder-tumour incidence in rats, compared with Epitalon

Digestive-enzyme activity in the gut of 3-month-old and 11-month-old rats

Gene-expression changes in mouse heart on a 15,247-clone microarray

Databases & peer-reviewed sources

Last reviewed: 13 October 2026 · New-U Research Compounds

Khavinson VKh, Anisimov VN. A synthetic dipeptide vilon (L-Lys-L-Glu) inhibits growth of spontaneous tumors and increases life span of mice. Dokl Biol Sci 2000. · 2000 · PMID: 10944717

Khavinson VK, Anisimov VN, Zavarzina NY, et al. Effect of vilon on biological age and lifespan in mice. Bull Exp Biol Med 2000. · 2000 · PMID: 11140587 · DOI: 10.1007/BF02682106

Khavinson VK, Morozov VG, Malinin VV, Kazakova TB, Korneva EA. Effect of peptide Lys-Glu on interleukin-2 gene expression in lymphocytes. Bull Exp Biol Med 2000. · 2000 · PMID: 11177276

Anisimov SV, Bokheler KR, Khavinson VKh, Anisimov VN. Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology. Bull Exp Biol Med 2002. · 2002 · PMID: 12360356 · DOI: 10.1023/a:1015859322630

Khavinson VK, Timofeeva NM, Malinin VV, Egorova VV, Nikitina AA. Effect of the dipeptide vilon on activity of digestive enzyme in rats of various ages. Bull Exp Biol Med 2001. · 2001 · PMID: 11586413 · DOI: 10.1023/a:1012319122696

Pliss GB, Mel'nikov AS, Malinin VV, Khavinson VKh. [Effect of vilon and epithalone on induction and growth of induced bladder neoplasms in rats]. Vopr Onkol 2001. · 2001 · PMID: 11785104

Khavinson VKh, Tarnovskaya SI, Lin'kova NS, et al. Role of peptide bond in the realization of biological activity of short peptides. Bull Exp Biol Med 2015. · 2015 · PMID: 25705040 · DOI: 10.1007/s10517-015-2805-0

Khavinson VK, Linkova NS, Ashapkin VV, et al. [KE peptide regulates SIRT1, PARP1, PARP2 gene expression and protein synthesis in human mesenchymal stem cells aging.]. Adv Gerontol 2023. · 2023 · PMID: 37782636

PubMed: peer-reviewed literature on Vilon

ClinicalTrials.gov: registered studies on Vilon

Vilon: Wikipedia (search)

WebMD: consumer health reference

BBC News: Health

CNN Health: “Peptides: what to know about the wellness trend”

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Sky News Australia: “Black market peptide trade explodes as influencers fuel uptick in use”

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Key Characteristics

Two-residue peptide: Lys-Glu (KE)

The shared stem of Testagen (Lys-Glu-Asp-Gly) and Vesugen (Lys-Glu-Asp)

Experimental record: rodent tumour and survival studies, interleukin-2 expression, heart microarray, human stem-cell culture

No controlled human trial in the cited literature

Average mass 275.30 Da (C11H21N3O5), free peptide

Supplied as 10 × 20 mg lyophilised vials or a single sample vial; no analytical report published yet

Specifications

Sequence Lys-Glu (KE) Residues 2 Molecular Formula C 11 H 21 N 3 O 5 Molecular Weight 275.30 Da (average, free peptide) Form Lyophilised powder Pack 10 vials × 20 mg Family Khavinson short-peptide bioregulator Analytical report None published yet Storage Lyophilised: −20 °C freezer. Reconstituted: 1-6 °C, away from light.

About Vilon (Lys-Glu, KE): Short-Peptide Bioregulator Research Guide

Vilon is the name the Khavinson group gave to the dipeptide L-Lys-L-Glu. Papers also write it as "vilon" or simply Lys-Glu or KE. As the smallest sequence in the programme, it is often used as a reference point: other family peptides are described as extensions of it, and the 2002 microarray and 2001 bladder-tumour papers set it beside Epitalon.

Its published history divides into two periods. The first, around 2000 to 2002, is whole-animal and cell-culture work from the Institute of Bioregulation and Gerontology and collaborators. The second is a 2015 paper on the role of the peptide bond and a 2023 paper on human mesenchymal stem cells, both aimed at how a dipeptide could act on DNA and gene expression.

New-U Research Compounds supplies Vilon as a lyophilised research powder, as a sealed 10-vial pack of 20 mg vials or as one sample vial. No analytical report for the supplied material has been published yet, and this page makes no purity or certificate claim. It is for in-vitro and preclinical research only, is not a medicine, and nothing here is medical advice.

Khavinson VKh, Anisimov VN. A synthetic dipeptide vilon (L-Lys-L-Glu) inhibits growth of spontaneous tumors and increases life span of mice. Dokl Biol Sci 2000.

Khavinson VK, Anisimov VN, Zavarzina NY, et al. Effect of vilon on biological age and lifespan in mice. Bull Exp Biol Med 2000.

Khavinson VK, Morozov VG, Malinin VV, Kazakova TB, Korneva EA. Effect of peptide Lys-Glu on interleukin-2 gene expression in lymphocytes. Bull Exp Biol Med 2000.

Anisimov SV, Bokheler KR, Khavinson VKh, Anisimov VN. Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology. Bull Exp Biol Med 2002.

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Research peptides. Third-party Certificates of Analysis (Janoshik Analytical & Freedom Diagnostics) are published on the website. Supplied strictly for laboratory research use.

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